TABLE 5.
Essential oil composition | Exposure | Hazard characterisation | Risk characterisation | |||||
---|---|---|---|---|---|---|---|---|
Assessment group | FLAVIS‐No | Highest conc. in the oil | Highest feed conc. | Daily intake 1 | Cramer class 2 | NOAEL 3 | MOE 4 | MOET 5 |
Constituent | – | % | mg/kg | mg/kg bw/day | – | mg/kg bw/day | – | – |
CG 3 | ||||||||
Geranyl acetate | 09.011 | 2.61 | 0.261 | 0.0234 | (I) | 345 | 14,730 | |
Neryl acetate | 09.213 | 1.37 | 0.137 | 0.0123 | (I) | 345 | 28,134 | |
(E)‐2‐Hexen‐1‐ol | – | 0.22 | 0.022 | 0.0020 | I | 3 | 1526 | |
MOET CG 3 | 1318 | |||||||
CG 6 | ||||||||
α‐Terpineol | 02.014 | 3.85 | 0.385 | 0.0346 | (I) | 125 6 | 3615 | |
Sclareol | 02.206 | 1.18 | 0.118 | 0.0106 | (I) | 4.4 7 | 414 | |
Spathulenol | – | 0.31 | 0.031 | 0.0028 | I | 3 | 1089 | |
3,7‐Dimethylocta‐1,5,7‐trien‐3‐ol | – | 0.07 | 0.007 | 0.0006 | II | 0.91 | 1513 | |
2‐(4‐Methylphenyl)propan‐2‐ol | 02.042 | 0.03 | 0.003 | 0.0003 | I | 3 | 10,780 | |
MOET CG 6 | 229 | |||||||
CG 7 | ||||||||
(2R,5E)‐Caryophyll‐5‐en‐12‐al | – | 0.05 | 0.005 | 0.0005 | I | 3 | 6305 | |
CG 8 | ||||||||
d,l‐Borneol | 02.016 | 0.13 | 0.013 | 0.0012 | (I) | 15 | 12,469 | |
d,l‐Bornyl acetate | 09.218 | 0.07 | 0.007 | 0.0006 | (I) | 15 | 23,207 | |
Acorenone B | – | 1.38 | 0.007 | 0.0006 | II | 0.91 | 1428 | |
MOET CG 8 | 1214 | |||||||
CG 9 | ||||||||
1,6‐Octadiene‐1,3‐diol, 3,7‐dimethyl‐ | – | 0.12 | 0.012 | 0.0011 | III | 0.15 | 137 | |
CG 10 | ||||||||
4‐Hydroxy‐4‐methylpentan‐2‐one | 07.165 | 0.04 | 0.004 | 0.0004 | I | 3 | 8569 | |
CG 13 | ||||||||
Linalool oxide | 13.140 | 0.03 | 0.003 | 0.0002 | II | 0.91 | 3899 | |
CG 15 | ||||||||
Phenyl acetaldehyde | 05.030 | 0.02 | 0.002 | 0.0002 | I | 3 | 15,913 | |
CG 16 | ||||||||
Sclareol oxide | – | 0.30 | 0.030 | 0.0027 | II | 0.91 | 337 | |
(Z)‐Dehydroxylinalool oxide | – | 0.06 | 0.006 | 0.0006 | II | 0.91 | 1609 | |
(E)‐Dehydroxylinalool oxide | – | 0.05 | 0.005 | 0.0004 | II | 0.91 | 2027 | |
β‐Dihydroagarofuran | – | 0.04 | 0.004 | 0.0006 | III | 0.15 | 398 | |
3,6‐Dihydro‐4‐methyl‐2‐(2‐methylprop‐1‐en‐1‐yl)‐2H‐pyran | 13.088 | 0.03 | 0.003 | 0.0002 | II | 0.91 | 3270 | |
MOET CG 16 | 145 | |||||||
CG 21 | ||||||||
4‐(4‐Methyl phenyl) pentanal | – | 0.04 | 0.004 | 0.0004 | I | 3 | 7595 | |
CG 31, I | ||||||||
Octane | – | 0.08 | 0.008 | 0.0007 | I | 3 | 4126 | |
Tridecane | – | 0.03 | 0.003 | 0.0003 | I | 3 | 11,523 | |
Nonane | – | 0.01 | 0.001 | 0.0001 | I | 3 | 27,848 | |
3‐Methylnonane | – | 0.01 | 0.001 | 0.0001 | I | 3 | 30,380 | |
MOET CG 31, I | 2513 | |||||||
CG 31, II (Acyclic alkanes) | ||||||||
Myrcene | 01.008 | 1.10 | 0.110 | 0.0098 | (I) | 44 | 4468 | |
(E)‐β‐Ocimene | – | 0.83 | 0.083 | 0.0074 | (I) | 44 | 5912 | |
(Z)‐β‐Ocimene | 01.064 | 0.54 | 0.054 | 0.0049 | (I) | 44 | 9060 | |
trans‐β‐Farnesene | – | 0.40 | 0.040 | 0.0036 | (I) | 44 | 12,346 | |
α‐Farnesene | 01.040 | 0.23 | 0.023 | 0.0010 | (I) | 44 | 21,591 | |
(E,E)‐7,11,15‐Trimethyl‐3‐methylene‐hexadeca‐1,6,10,14‐tetraene | – | 0.11 | 0.011 | 0.0010 | I | 3 | 2984 | |
MOET CG 31, II | 1035 | |||||||
CG 31, IV (Benzene hydrocarbons, alkyl) | ||||||||
(E)‐1‐(6,10‐Dimethylundeca‐5,9‐dien‐2‐yl)‐4‐methylbenzene | – | 0.05 | 0.005 | 0.0004 | I | 3 | 6305 | |
Isopentyl curcumene | – | 0.06 | 0.003 | 0.0003 | I | 3 | 10,780 | |
MOET CG 31, IV | 3978 | |||||||
CG 31, V (Bi‐, tricyclic, non‐aromatic hydrocarbons) | ||||||||
β‐Caryophyllene | 01.007 | 2.66 | 0.266 | 0.0210 | (I) | 222 | 9283 | |
Bicyclogermacrene | – | 1.20 | 0.120 | 0.0095 | (I) | 222 | 20,608 | |
α‐Copaene | – | 1.15 | 0.115 | 0.0091 | (I) | 222 | 21,504 | |
MOET CG 31, V | 4932 | |||||||
CG 31, VI (macrocyclic non‐aromatic hydrocarbons) | ||||||||
Germacra‐1(10),4(14),5‐triene | 01.042 | 6.46 | 0.646 | 0.0580 | I | 3 | 52 | |
CG 32 | ||||||||
β‐Caryophyllene epoxide | 16.043 | 0.36 | 0.036 | 0.0032 | (III) | 109 | 33,634 | |
Epoxylinalyl acetate | – | 0.05 | 0.005 | 0.0005 | III | 0.15 | 321 | |
6,10‐Epoxy‐7(14)‐isodaucane | – | 0.04 | 0.004 | 0.0004 | III | 0.15 | 389 | |
19,975 |
Intake calculations for the individual components are based on the use level of 10 mg/kg in feed for chickens for fattening, the species with the highest ratio of feed intake/body weight.
When a NOAEL value is available or read‐across is applied, the allocation to the Cramer class is put into parentheses.
Values in bold refer to those components for which the NOAEL value was available, values in italics are the 5th percentile of the distribution of NOAELs of the corresponding Cramer Class, other values (plain text) are NOAELs extrapolated by using read‐across.
The MOE for each component is calculated as the ratio of the reference point (no observed adverse effect level, NOAEL) to the intake.
The combined margin of exposure (MOET) is calculated for each assessment group as the reciprocal of the sum of the reciprocals of the MOE of the individual substances.
An uncertainty factor of 2 was applied to the NOAEL of 250 mg/kg bw per day for terpineol (short duration of the study).
An uncertainty factor of 2 was applied to the NOAEL of 8.8 mg/kg bw per day for sclareol (short duration of the study).