Table 2.
Comparison of Plaque Characteristics According to Pre-Existing Disease Patterns by FFRCT and FFRCT Gradient
| Local Severity | FFRCT Gradient <0.025/mm |
FFRCT Gradient ≥0.025/mm |
P Value | ||
|---|---|---|---|---|---|
| FFRCT >0.80 (n = 311) | FFRCT ≤0.80 (n = 107) | FFRCT >0.80 (n = 41) | FFRCT ≤0.80 (n = 175) | ||
| Interrogated vessels | <0.001 | ||||
| Left anterior descending artery | 93 (29.9) | 31 (29.0) | 19 (46.3) | 92 (52.6) | |
| Left circumflex artery | 99 (31.8) | 43 (40.2) | 13 (31.7) | 30 (17.1) | |
| Right coronary artery | 119 (38.3) | 33 (30.8) | 9 (22.0) | 53 (30.3) | |
| Anatomic severity | |||||
| Diameter stenosis, % | 40.7 ± 23.3 | 53.6 ± 23.4 | 47.8 ± 26.7 | 61.0 ± 20.2 | <0.001 |
| Lesion length, mm | 20.0 ± 15.8 | 21.3 ± 17.6 | 23.0 ± 17.7 | 27.5 ± 18.3 | 0.008 |
| Maximum plaque burden, % | 77.7 ± 11.6 | 83.9 ± 11.5 | 83.1 ± 12.0 | 88.0 ± 9.6 | <0.001 |
| Minimum lumen area, mm2 | 2.92 ± 1.97 | 1.70 ± 1.50 | 2.06 ± 2.02 | 1.43 ± 1.41 | <0.001 |
| Anatomic plaque characteristics | |||||
| Total aggregate plaque volume in vessel, % | 45.9 ± 6.3 | 51.2 ± 7.1 | 48.6 ± 8.3 | 52.2 ± 8.0 | <0.001 |
| Plaque volume in lesion, % | 55.4 ± 8.0 | 61.5 ± 8.4 | 59.2 ± 8.4 | 62.0 ± 9.0 | <0.001 |
| Calcified volume in lesion, % | 10.6 ± 6.9 | 13.4 ± 10.1 | 10.9 ± 10.0 | 11.9 ± 7.9 | 0.170 |
| Lipid-rich necrotic core volume in lesion, % | 0.4 ± 1.0 | 0.3 ± 1.0 | 0.3 ± 0.7 | 0.8 ± 1.5 | 0.027 |
| Intraplaque hemorrhage volume in lesion, % | 1.1 ± 2.3 | 1.4 ± 2.9 | 3.3 ± 4.9 | 1.7 ± 2.9 | 0.007 |
| Physiologic plaque characteristics | |||||
| FFRCT | 0.90 ± 0.05 | 0.72 ± 0.07 | 0.84 ± 0.04 | 0.66 ± 0.10 | <0.001 |
| FFRCT gradient (dFFRCT/ds), per mm | 0.011 ± 0.005 | 0.017 ± 0.005 | 0.034 ± 0.008 | 0.055 ± 0.034 | <0.001 |
Values are as n (%) or mean ± SD.
FFRCT = fractional flow reserve by coronary computed tomography angiography.