Table 2. Patient and Clinical Characteristics by Trajectory.
| Characteristics | Patients, No. (%) | ||
|---|---|---|---|
| Trajectory 1 (N = 551) | Trajectory 2 (N = 293) | Trajectory 3 (N = 164) | |
| Age at diagnosis, median (IQR), y | 37 (33-39) | 36 (33-39) | 37 (32.5-39) |
| Age | |||
| Emerging adults (age 17-25) | 6 (1.1) | 9 (3.1) | 4 (2.4) |
| Young adults (age 26-40) | 545 (98.9) | 284 (96.9) | 160 (97.6) |
| BMI | |||
| <25 | 395 (71.7) | 182 (62.1) | 77 (47.0) |
| ≥25 | 154 (28.0) | 109 (37.2) | 85 (51.8) |
| Race | |||
| American Indian or Alaskan | 1 (0.2) | 2 (0.7) | 1 (0.6) |
| Asian | 38 (6.9) | 12 (4.1) | 10 (6.1) |
| Black of African American | 12 (2.2) | 14 (4.8) | 9 (5.5) |
| White | 490 (88.9) | 263 (89.8) | 131 (79.9) |
| >1 category reported | 4 (0.7) | 2 (0.7) | 7 (4.3) |
| Other or unknowna | 6 (1.1) | 0 | 6 (3.7) |
| Hispanic or Latino | |||
| Yes | 15 (2.7) | 18 (6.1) | 14 (8.5) |
| No | 536 (9.2) | 274 (93.5) | 148 (90.2) |
| Missing | 0 | 1 (0.3) | 2 (1.2) |
| Highest level of education at diagnosisb | |||
| Non–college graduate | 49 (8.9) | 56 (19.1) | 58 (35.4) |
| College graduate | 502 (91.1) | 235 (80.2) | 103 (62.8) |
| Missing | 0 | 2 (0.7) | 3 (1.8) |
| Partnered at baseline | |||
| Yes | 456 (82.8) | 216 (73.7) | 92 (56.1) |
| No | 92 (16.7) | 76 (25.9) | 69 (42.1) |
| Missing | 3 (0.5) | 1 (0.3) | 3 (1.8) |
| Parous at diagnosis | |||
| Yes | 349 (63.3) | 199 (67.9) | 101 (61.6) |
| No | 202 (36.7) | 94 (32.1) | 63 (38.4) |
| Employment status at time of diagnosis | |||
| Employed at baseline and 1 y | 246 (44.7) | 110 (37.5) | 43 (26.2) |
| Not employed at baseline or 1 y | 186 (33.8) | 110 (37.5) | 61 (37.2) |
| Gained employment at 1 y | 58 (10.5) | 27 (9.2) | 20 (12.2) |
| Lost employment at 1 y | 16 (2.9) | 12 (4.1) | 10 (6.1) |
| Unknown or censored | 45 (8.2) | 34 (11.6) | 30 (18.3) |
| Any comorbid condition | 46 (8.4) | 30 (10.2) | 24 (14.6) |
| Stage at diagnosis | |||
| 0 | 52 (9.4) | 22 (7.5) | 12 (7.3) |
| I | 210 (38.1) | 98 (33.5) | 46 (28.1) |
| II | 213 (38.7) | 133 (45.4) | 78 (47.6) |
| III | 76 (13.8) | 40 (13.7) | 28 (17.1) |
| ER/PR positive | |||
| Yes | 414 (75.1) | 218 (74.4) | 122 (74.4) |
| No | 137 (24.9) | 74 (25.3) | 42 (25.6) |
| Missing | 0 | 1 (0.3) | 0 |
| ERBB2 positive | |||
| Yes | 157 (28.5) | 72 (24.6) | 44 (26.8) |
| No | 366 (66.4) | 207 (70.7) | 113 (68.9) |
| Missing | 28 (5.1) | 14 (4.8) | 7 (4.3) |
| Surgery | |||
| Lumpectomy | 168 (30.5) | 85 (29.0) | 44 (26.8) |
| Unilateral mastectomy | 147 (26.7) | 72 (24.6) | 36 (22.0) |
| Bilateral mastectomy | 236 (42.8) | 136 (46.4) | 84 (51.2) |
| Radiation | |||
| Yes | 339 (61.5) | 188 (64.2) | 100 (61.0) |
| No | 212 (38.5) | 105 (35.8) | 64 (39.0) |
| Chemotherapy | |||
| Yes | 397 (72.1) | 223 (76.1) | 140 (85.4) |
| No | 154 (28.0) | 70 (23.9) | 24 (14.6) |
| Endocrine therapyc | |||
| Yes | 352 (63.9) | 164 (62.8) | 94 (57.3) |
| No | 197 (35.8) | 109 (37.2) | 70 (42.7) |
| Missing | 2 (0.4) | 0 | 0 |
| Arm morbidity within 2 y of diagnosisd | |||
| Yes | 375 (68.1) | 216 (73.7) | 130 (79.3) |
| No | 172 (31.2) | 76 (25.9) | 31 (18.9) |
| Missing | 4 (0.7) | 1 (0.3) | 3 (1.8) |
Abbreviations: BMI, body mass index (calculated as weight in kilograms divided by height in meters squared); ER, estrogen receptor; PR, progesterone receptor.
a
Other race includes American Indian, Alaskan Native, Native Hawaiian, and Pacific Islander.
b
Non–college degree includes some college and those with vocational training; college graduate includes those with postcollege graduate degrees or professional degrees.
c
Any endocrine therapy from baseline to 1 year.
d
Arm morbidity as defined by patient-reported composite of arm swelling and decreased range of motion.