TABLE 3.
Effect of the J. regia extract on serum biochemical parameters for the liver injury tests.
| Parameters | Experimental group | |||||
|---|---|---|---|---|---|---|
| Normal control (10 mL/kg DW) | Toxic control (10 mL/kg DW) | Standard test (Silymarin 100 mg/kg) | J. regia extract (500 mg/kg) | J.regia extract (250 mg/kg) | J. regia extract (125 mg/kg) | |
| AST | 131.02 ± 2.75 | 372.45 ± 3.74 | 196.72 ± 2.09 (72.78) | 223.52 ± 3.48 (61.68) | 269.96 ± 3.51 (42.45) | 320.75 ± 5.31 (21.41) |
| ALT | 27.4 ± 1.13 | 115.87 ± 9.25 b | 33.58 ± 1.13 d (93.01) | 51.19 ± 0.94 d (73.1) | 66.99 ± 1.71 d (55.25) | 93.99 ± 1.07 c (17.94) |
| ALP | 134.01 ± 1.48 | 344.98 ± 15.90 b | 176.79 ± 2.88 d (79.72) | 226.90 ± 2.66 d (55.97) | 251.73 ± 1.70 d (44.2) | 281.15 ± 0.93 d (30.25) |
| TP | 8.51 ± 0.07 | 7.25 ± 0.07 | 8.18 ± 0.01 (73.8) | 8.06 ± 0.02 (64.28) | 8.01 ± 0.01 (60.31) | 7.76 ± 0.04 (40.47) |
| DBI | 0.21 ± 0.02 | 0.96 ± 0.003 b | 0.63 ± 0.01 d (44) | 0.74 ± 0.01 d (29.34) | 0.86 ± 0.001 d (13.34) | 0.91 ± 0.08 (6.67) |
| TBI | 0.38 ± 0.007 | 0.80 ± 0.03 b | 0.46 ± 0.003 d (80.95) | 0.54 ± 0.01 d (61.9) | 0.59 ± 0.01 d (50) | 0.65 ± 0.01 d (35.71) |
| Albumin | 3.84 ± 0.14 | 0.46 ± 0.003 a | 3.42 ± 0.20 d (87.57) | 3.14 ± 0.07 d (79.28) | 2.89 ± 0.02 d (71.89) | 2.69 ± 0.03 c (65.97) |
Note: The results represent the mean and standard error of mean (SEM) of six rats. Numbers in parentheses indicate % hepatoprotection.
Abbreviation: DW, distilled water.
a
p < .05 substantially different from the normal group (given DW only).
b
p < .001 considerable variation with the normal group (given DW only).
c
p < .05 substantially different from the toxic group (group was given DW and CCl4).
d
p < .001 considerably different from the toxic group (group was given DW and CCl4).