TABLE 1.

Demographics of each cohort.

	Tracer head‐to‐head comparison
		Training				Simulation
		Single‐tracer		Mixed‐tracer		Single‐tracer		Mixed‐tracer
	Head‐to‐head	FBP	PiB	FBP	PiB	FBP	PiB	FBP	PiB
Number of subjects	99	301	452	219	219	153	150	60	60
Number of scans	113	325	656	240	388	173	200	85	122
Mean age at scan (± sd)	69 ± 8.48	72.3 ± 7.63***	70.2 ± 9.57✝✝✝	70.6 ± 8.4	66.9 ± 8.66*,✝✝✝✝	73.1 ± 7.24	74.5 ± 7.27	74.4 ± 7.02	70.8 ± 6.9✝✝✝
Number of males/females	45/54	145/156	205/247	78/141	78/141	55/98	84/66✝✝✝	22/38	22/38
APOE noncarriers/carriers	67/32	179/122	283/169	158/61	158/61	78/75	52/98✝✝	26/34	26/34
Number of CDR = 0/CDR = 0.5/CDR > 1	108/4/1	250/58/17****	527/104/25***	230/9/1	373/14/1	114/45/14	116/63/21	75/8/2	116/5/1
Number of scans per subject (± sd)	1.1 ± 0.38	1.1 ± 0.27	1.5 ± 0.76	1.1 ± 0.31	1.8 ± 0.9	1.1 ± 0.39	1.3 ± 0.67	1.4 ± 0.65	2 ± 1.12
Mean years between scans (± sd)	1.6 ± 0.53	3 ± 0.82	3.5 ± 1.81	3 ± 0.92	4.2 ± 2.17	2.5 ± 1.25	3.2 ± 1.49	1.8 ± 0.78	3.4 ± 1.54

Note: The training dataset of the head‐to‐head comparison was split into subjects who were scanned with only one tracer (single‐tracer) and those who were scanned with multiple tracers (mixed‐tracer). Statistically significant differences are denoted with asterisks and crosses. Asterisks (*) indicate comparisons between head‐to‐head and each of the 4 training sub‐cohorts, whereas crosses (✝) indicate FBP versus PiB comparisons within a single/mixed tracer cohort. The number of symbols indicates the significance level (1 = p < 0.05, 2 = p < 0.01, 3 = p < 0.005, 4 = p < 1e‐4). Note that the reported CDRs are counted by scans, where the closest CDR score in time was assigned to every scan.

Abbreviations: APOE = apolipoprotein‐E4; CDR = Clinical Dementia Rating; sd = standard deviation.