Fig. 11.

PAE attenuates the ER stress in the striatum of MPTP-treated mice via AKT pathway. A The expression of AKT-pathway molecules in the striatum was detected by western-bot. PAE administration attenuated the reduction of p-AKT/AKT ratio (B), p-GSK3β/ GSK3β (C) and β-catenin (D). E, I The expression of indicators related to ER stress in the striatum was examined. PAE suppressed the up-regulation of p-IRE1α/IRE1α ratio (F), p-JNK/JNK (G), cleaved caspase-3 (H), GRP78 (J), p-eIF2α/ eIF2α ratio (K) and CHOP (L) in the striatum of MPTP-treated mice, MK-2206 blocked the effects of PAE. Data are presented as mean ± SD, n = 3, ^*p < 0.05, ^**p < 0.01, ^***p < 0.001, vs. control group, ^#p < 0.05, ^##p < 0.01, ^###p < 0.001, vs. MPTP group, ^{^}p < 0.05, ^{^^}p < 0.01, vs. MPTP + PAE group