Table 1.
Patient Demographics, Clinical/Laboratory Data at Diagnosis, and Comparison of Takayasu Arteritis (TAK) and Giant Cell Arteritis (GCA)
Total, n = 51 | TAK, n = 24 | GCA, n = 27 | P | |
---|---|---|---|---|
Female, n (%) | 37 (73) | 18 (75) | 19 (70) | .712‡ |
Age at onset, mean (SD) years | 50 (22.4) | 28 (9.2) | 69 (6.6) | <.0001* |
Age at diagnosis, mean (SD) years | 52 (21.7) | 30 (10.0) | 70 (6.3) | <.0001* |
Delay from onset to diagnosis, median (IQR) months | 4 (2-13) | 7 (2-30) | 3 (2-9) | .021† |
CRP level at diagnosis, median (IQR) mg/l | 8.3 (4.6-12.7) | 6.4 (3.1-12) | 8.3 (6.5-13.2) | .209† |
ESR at diagnosis, median (IQR) mm/h | 72 (53-103) | 62 (48-71) | 88 (73-116) | .001† |
Symptoms | ||||
Fever at diagnosis, no. (%) | 33 (65%) | 16 (67%) | 17 (63%) | .782‡ |
Arthralgia, myalgia at diagnosis, no. (%) | 11 (22%) | 1 (4%) | 10 (37%) | .004‡ |
Limb claudication at diagnosis, no. (%) | 12 (24%) | 9 (38%) | 3 (11%) | .027‡ |
Pulse loss or weakness at diagnosis, no. (%) | 9 (18%) | 6 (25%) | 3 (11%) | .176‡ |
Blood pressure inequality at diagnosis, no. (%) | 17 (33%) | 12 (50%) | 5 (19%) | .017‡ |
Bruit at diagnosis, no. (%) | 19 (37%) | 17 (71%) | 2 (7%) | <.0001‡ |
Carotidynia at diagnosis, no. (%) | 15 (29%) | 10 (42%) | 5 (19%) | .07‡ |
Chest or back pain at diagnosis, no. (%) | 13 (26%) | 11 (46%) | 2 (7%) | .002‡ |
Headache at diagnosis, no. (%) | 9 (18%) | 2 (8%) | 7 (26%) | .1‡ |
Temporal artery abnormality at diagnosis, no. (%) | 9 (18%) | 0 | 9 (33%) | .002‡ |
Polymyalgia rheumatica at diagnosis, no. (%) | 4 (8%) | 0 | 4 (15%) | .07‡ |
Positive temporal artery biopsy at diagnosis, no. (%) | 7 (14%) | 0 | 7 (26%) | .008‡ |
Jaw claudication at diagnosis, no. (%) | 6 (12%) | 0 | 6 (22%) | .016‡ |
Visual loss, no. (%) | 4 (8%) | 0 | 4 (15%) | .07‡ |
Complications | ||||
Ulcerative colitis, no. (%) | 6 (12%) | 6 (25%) | 0 | .007‡ |
Hypertension, no. (%) | 27 (53%) | 9 (38%) | 18 (67%) | .037‡ |
Hyperlipidaemia, no. (%) | 20 (40%) | 8 (33%) | 12 (44%) | .417‡ |
Diabetes mellitus, no. (%) | 11 (22%) | 1 (4%) | 10 (37%) | .004‡ |
Smoking, no. (%) | 14 (28%) | 6 (25%) | 8 (29%) | .712‡ |
Treatment | ||||
Glucocorticoids, no. (%) | 51 (100%) | 24 (100%) | 27 (100%) | 1‡ |
Initial dose of glucocorticoids, median (IQR) mg/day | 50 (40-50) | 50 (42-55) | 40 (30-40) | <.001† |
The P values are calculated for the differences between TAK and GCA.
CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; IQR, interquartile range.
*t-test.
† Mann–Whitney U-test.
‡ chi-square test or Fisher’s exact test with Bonferroni correction.