Table 3.

Reported secondary outcome measures at each time point for year 1 and year 2 completers

Secondary Outcome Measure
Month	Baseline	3	6	9	12	15	18	21	24
SOFAS
Year 1 completers
n	108	106	101	104	105	95	77	57	33
Mean ± s.d	50.4 ± 11.62	57.4 ± 11.41***	57.9 ± 11.37***	59.4 ± 12.31***	61.0 ± 12.86***	61.0 ± 13.41***	62.1 ± 12.73***	62.4 ± 12.93***	65.1 ± 11.57***
Year 2 completers
n	33	33	31	33	33	33	33	33	33
Mean ± s.d	52.6 ± 11.38	58.0 ± 10.37**	60.8 ± 11.73***	60.7 ± 10.83***	64.1 ± 12.63***	63.7 ± 11.50***	63.9 ± 9.45***	64.1 ± 11.66***	65.1 ± 11.57***
CGI-S
Year 1 completers
n	108	105	100	103	106	93	74	54	32
Mean ± s.d	4.1 ± 0.78	3.5 ± 0.86***	3.3 ± 0.84***	3.2 ± 0.93***	3.1 ± 0.96***	3.1 ± 0.93***	3.0 ± 0.94***	3.0 ± 0.98***	2.9 ± 0.76***
Year 2 completers
n	33	33	31	33	33	33	31	33	32
Mean ± s.d	3.8 ± 0.68	3.4 ± 0.66**	3.2 ± 0.73***	3.2 ± 0.80***	3.0 ± 0.88***	2.9 ± 0.70***	2.9 ± 0.81***	2.9 ± 0.86***	2.9 ± 0.76***
Total BPRS
Year 1 completers
n	108	106	102	104	105	95	77	57	33
Mean ± s.d	40.2 ± 11.05	33.3 ± 10.08	30.7 ± 7.80	29.3 ± 7.83	29.2 ± 8.27	28.7 ± 7.70	27.2 ± 7.89	26.9 ± 7.01	25.5 ± 5.28
Year 2 completers
n	33	33	32	33	33	33	33	33	33
Mean ± s.d	40.3 ± 13.06	34.6 ± 11.91	31.5 ± 8.29	28.6 ± 6.96	30.2 ± 9.66	28.2 ± 6.21	26.5 ± 5.75	26.6 ± 5.62	25.5 ± 5.28

The total score for SOFAS ranges from 0 to 100. Reported. The CGI-S ranges from 1–7, where a score of 1 indicates no psychopathology and a score of 7 indicates severe psychopathology. The total BPRS ranges from 0–7: 0 = not assessed, 1 = not present, 2 = very mild, 3 = mild, 4 = moderate, 5 = moderately severe, 6 = severe, 7 = extremely severe. Total Score is calculated by adding 18 subscores for each subject at each visit. P value was calculated by using paired t-test of scores at each time point vs baseline defined as time of enrollment into the study. * p < 0.05, *** p < 0.001. BPRS Brief Psychiatric Rating Scale, CGI-S Clinical Global Impression-Severity scale, SOFAS Social and Occupational Functioning Scale