Table 3.
Types of multi-enzyme-like activity of nanozymes
| Multi-enzyme-like type | Enzyme type | Number of publications | Representative nanozymes | Application |
|---|---|---|---|---|
| Bi-enzyme | OXD-POD | 1040 |
MnNS [68], Co/2Fe MOF [69] |
Detection, Detection |
| GOX-POD | 326 |
g-C3N4 [70], DMSN-Au-Fe3O4 NPs [71] |
Detection, Anti-tumor |
|
| POD-CAT | 190 |
Fe3O4 NPs [72], Co3O4 nanoplates [73] |
Diminishing cytotoxicity, Detection |
|
| GPX-OXD | 20 |
CuGQD/PdNPs@Psi [74], Mo/Fe@CuO2 [75] |
Anti-cancer, Anti-bacterial |
|
| SOD-CAT | 102 |
Pt/Co-SA-NSG [76], CeO2 NPs [77] |
Treatment of osteoarthritis, Treatment of ischemia–reperfusion injury |
|
| OXD-CAT | 68 |
DOX@CuMn-Dazymes [78], Co-SAs@NC [79] |
Treatment of tumor, Anti-cancer |
|
| COX-POD | 5 |
Cu-BTC [80], U66-PV-Pep@AuNP [81] |
Detection, Detection |
|
| AAO-POD | 7 | CuO NPs/AA [82] | Anti-bacterial | |
| POD-LAC | 4 | Cu FMA [83] | Detection | |
| Protease-SOD | 1 | AuNPs@POMD-8pep-6pep NPs [84], | Treatment of Alzheimer’s disease | |
| UOX-CAT | 5 | Pt/CeO2 [85] | Treatment of acute gout | |
| GPX-CAT | 2 | Sn Fe2O4 [86] | Anti-cancer | |
| Tri–enzyme | OXD-CAT-POD | 159 |
Co3O4/CoFe2O4 HNCs [87], Ir-N-5 SA [88] |
Environmental governance, Anti-cancer |
| SOD-CAT-POD | 105 |
Au/CeO2 [89], NLRP3 [90] |
Detection, Anti-inflammation |
|
| SOD-CAT-UOX | 2 | ARP-PtNC [91] | Treatment of gout and hyperuricemia | |
| Tetra-enzyme | OXD-POD- SOD-CAT | 57 |
polymer-coated/CeO2 [92], hNiPt@CoNC [93] |
Anti-oxidant, Detection |
| OXD-POD-CAT-GPX | 15 | CuO NP-POM [94] | Detection | |
| POD-CAT-SOD-AOX | 4 | Cu NCs [95] | Detection | |
| Laccase-POD-OXD-CAT | 5 | Co1.5Mn1.5O4 [96] | Detection | |
| Penta-enzyme | POD-OXD- UOD-SOD-CAT | 1 | Pero-nanozysome [97] |
Treatment of hyperuricemia and ischemic stroke, |
| SOD-POD-LOX-GPX-NDH | 1 | TADI-COF-Fc [98] | Anti-cancer |