Table 1.

Potencies at producing MDMA- and methamphetamine-like (Meth) discriminative stimulus effects. ED₅₀ values were calculated from total session data. DAT/SERT selectivity refers to relative potency for inhibition of transmitter uptake by DAT over SERT.

Training Drug	MDMA (mg/kg)	Meth (mg/kg)	MDMA/Meth Potency Ratio	DAT/SERT
Test Compound				Selectivity4
MDMA	0.67±0.05	2.09±0.06	3.12	0.88
Methamphetamine	0.86±0.07	0.33±0.13	0.37	111.00
Methcathinone	--	0.34±0.082	NA	136.00
Flephedrone	5.27±0.08	2.85±0.081	0.54	>36
Mephedrone	0.59±0.17	1.42±0.061	2.41	5.2
Pentedrone	2.00±0.11	2.67±0.182	1.34	51
Ethylone	4.57±0.06	5.01±0.083	1.10	.27
4-MEC	6.04±0.10	8.69±0.132	1.44	.23
3-FMC	0.86±0.10	0.74±0.072	0.86	60.3

¹ Gatch et al., 2013

² Gatch et al., 2015

³ Gatch et al., 2017

⁴ Eshleman et al., 2017