Figure 7.

Reversibility of growth inhibition induced by cyclic mechanical stretch (CMS) and hyperoxia (HOX) in lung resident mesenchymal stem cells (MSC) depending on strength and duration of the exposure (HOX 80%). A: bright-field microscopy of proliferation after 24 h of selective and/or combined exposure to CMS and HOX 80%. Outgrowth (OG) of cells in all intervention groups after further 3 and 7 days of recovery in room air without CMS. B: bright-field microscopy of proliferation after 72 h of selective and/or combined exposure to CMS and HOX 80%. OG of cells only in the CMS selective treatment group but not in any of the HOX groups after 3 and 7 days of recovery in room air without CMS. Representative experiments of n = 3.