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Conditional knockout of Spns1 impairs proximal tubule endocytosis. A: low molecular weight proteinuria in Spns1 knockouts. Coomassie staining is shown. B: urinary NGAL excreted in Spns1 knockouts. C: exogenous Alexa568-transferrin and -NGAL excreted in Spns1 knockout. Urine immunoblots are shown. D and E: failure to capture FITC-NGAL and FITC-dextran despite expression of megalin in Megalin3’Cre-Ert;Spns1flox/flox knockout proximal tubules. Bars = 20 µm in D and 80 µm in E.
