Figure 8.

Sex differences in the role of renin on spontaneous sniffer cell activity are observed in MnPO slices. Males exhibit a more pronounced decrease in sniffer cell activity following renin inhibition than females in wild-type rats (A). In heterozygous renin KO rats, females exhibit a greater basal sniffer cell activity than males but both males and females show similar sniffer cell activity in response to renin inhibition (B). Male and female homozygous renin KO rats show similar basal levels of sniffer cell activity that is insensitive to renin inhibition (C). ***P < 0.001, **P < 0.01 compared with baseline. #P < 0.05 compared with the baseline from males. KO, knockout rats; MnPO, median preoptic nucleus.