Figure 10. Scheme for a direct LEC-vCA1 projection pathway and the role of low-gamma oscillations and inter-regional entrainment in driving fear extinction, orchestrated by vCA1 PV-INs.

This cortical-subcortical motif can be therapeutically targeted through either vCA1 DBS or LEC tACS to enhance feedforward inhibition of fear-tagged neurons, thereby augmenting extinction to remove traumatic memories.