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. 2024 Nov 14;28(22):e70188. doi: 10.1111/jcmm.70188

FIGURE 4.

FIGURE 4

Flubendazole affects ferroptosis‐related protein expression in glioblastoma cells. (A, B) After the drug treatment, LN229 and U251 cells showed decreased expression of xCT, FHL and GPX 4, Accumulation of TFRC, DMT 1 and p53 (Flubendazole, 0, 0.125, 0.25, 0.5 μM, 24 h); (C, D) GPX4 depletion in U251 and LN229 cells treated with drugs (Flubendazole, 0.5 μM, 24 h; 400X, 1: 50 μm). (E–G) Flubendazole binds to two sites 229 Gly and 314 Arg in xCT protein. (2D diagram); (F, H) Flubendazole binds to two sites 457 Thr and 516 Gly in TFRC protein. (Student's t‐test was used.).