Table 2.
Sensitivity, false-positive rate, positive predictive value and negative predictive value of the C-Lung-RADS and Lung-RADS v2022
| Variables | C-Lung-RADS | Lung-RADS | P value | ||
|---|---|---|---|---|---|
| Percentage (95% CI) | n/N | Percentage (95% CI) | n/N | ||
| Internal testing dataset | |||||
| SEN | 79.9 (74.0–84.8) | 167/209 | 60.3 (53.5–66.7) | 126/209 | <0.001 |
| FPR | 8.2 (6.8–10.0) | 94/1,142 | 5.1 (3.9–6.5) | 58/1,142 | 0.003 |
| PPV | 64.0 (58.0–69.6) | 167/261 | 68.5 (61.5–74.8) | 126/184 | 0.325 |
| NPV | 96.1 (94.8–97.1) | 1,048/1,090 | 92.9 (91.3–94.2) | 1,084/1,167 | <0.001 |
| Independent testing dataset | |||||
| SEN | 87.1 (80.5–91.7) | 121/139 | 63.3 (55.0–70.9) | 88/139 | <0.001 |
| FPR | 5.9 (4.9–7.1) | 107/1,812 | 4.4 (3.5–5.4) | 79/1,812 | 0.035 |
| PPV | 53.1 (46.6–59.4) | 121/228 | 52.7 (45.2–60.1) | 88/167 | 0.941 |
| NPV | 99.0 (98.4–99.3) | 1,705/1,723 | 97.1 (96.3–97.8) | 1,733/1,784 | <0.001 |
Statistical analyses were performed using chi-square tests, with two-tailed P values presented. SEN, sensitivity; PPV, positive predictive value; NPV, negative predictive value.