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. 2024 Sep 16;30(11):3223–3235. doi: 10.1038/s41591-024-03249-3

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Extended Data Fig. 5 — a. Gating strategy used for the flow cytometry data analysis. b. Spearman correlation between fraction of activated Tregs and the change in tumor size on MRI (%). c. Spearman correlation between fraction of non-activated Tregs and the change in tumor size on MRI (%). Activated Tregs were defined as activated by the expression of CD137. d–e. Fold change in activated (d) and non-activated (e) Tregs after anti-PD-1 or anti-PD-1/anti-CTLA4 therapy. n = 22 patients. In B-C, correlation was estimated with Spearman’s rank correlation coefficient, two-sided, with 95% confidence interval for the regression estimate. In D–E, boxplots display a minimum (Q0), a maximum (Q4), a median (Q2) and the interquartile range. P values were derived using a two-sided Mann–Whitney test.