Extended Data Fig. 4. Copy number aberration (CNA) detected in the sc/snRNA-Seq data.

a,b) CNA heatmaps across malignant cells, grouped by sample, for snRNA-Seq data (panel a) and scRNA-Seqdata (panel b) c) CNA heatmaps for both samples from patient 223. Samples were taken from different liver lesions, 300 days apart and processed with snRNA-Seq. d) CNA heatmaps for both samples from patient 262. Samples were taken from the same liver lesion at the same time but processed with snRNA-Seq and scRNA-Seq respectively. e) CNA heatmaps for both samples from patient 862. Samples were taken from the same breast lesion but 220 days apart, and processed with snRNA-Seq. f) CNA heatmaps for both samples from patient 887. Samples were taken from the same axilla lesion but 200 days apart, and processed with snRNA-Seq.