Table 2.
Synergistic effect of AMP-17 in combination FLC on preformed C. albicans biofilm.
| No | SMEC80 | |||
|---|---|---|---|---|
| Agents alone | Combination | |||
| AMP-17 (μg/mL) | FLC (μg/mL) | AMP-17/FLC | FECI | |
| SC 5314 | 128 | >512 | 32/32 | 0.28 (S) |
| 16229 | 128 | >512 | 128/>512 | 3.0 (I) |
| 16138 | 128 | >512 | 128/32 | 1.03 (I) |
| 16162 | 128 | >512 | 128/32 | 1.03 (I) |
| 16228 | 128 | >512 | 128/32 | 1.03 (I) |
| 16225 | 128 | >512 | 32/512 | 0.75 (PS) |
| 16102 | 128 | >512 | 64/512 | 0.75 (PS) |
| 16230 | >128 | >512 | >128/>512 | 2.0 (I) |
| 16105 | 128 | >512 | 32/32 | 0.28 (S) |
| 16214 | 128 | >512 | 128/32 | 1.03 (I) |
| 16111 | 128 | >512 | 128/>512 | 3.0 (I) |
AMP-17, FLC, SMEC and FECI denoted antimicrobial peptide 17, fluconazole, the sessile minimum eradication concentration of the drug, and fractional eradication concentration index. SMEC was determined as 80% of eradication preformed C. albicans biofilm compared to growth control. S, synergism (FECI < 0.5); PS, partial synergism (0.5 ≤ FICI < 1.0); AE, additive effect (FICI = 1.0); I, indifference (1.0 < IFCI ≤ 4.0).