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. 2024 Nov 14;14:27952. doi: 10.1038/s41598-024-78274-w

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 3 — LocusFocus Manhattan plots for rs3780395 and rs7023227 in (A) the UK Biobank and (B) the CCSS-Rad-study GWAS results for tinnitus. Trendlines represent the most significant regional variant associations in eQTL datasets for PD-L1 expression. Only tissues with significant colocalization are included. Details of the colocalization analyses are provided in Supplemental Figs. 4 and 5. GWAS variants with − log10(p) < 1 are excluded from the plot. For plotting B, reference and alternative allele information were inferred from UK Biobank. Gray areas highlight the 100 kb distance from the GWAS lead variants that were used for the colocalization analyses.