Table 1.
The lead variants in loci with genome wide association p < 5 × 10–8 for tinnitus in UK Biobank.
| Chr:Pos:Ref/Alt | rsID | p-value | Beta | Gene(s) | Var_pos | QTL | ||
|---|---|---|---|---|---|---|---|---|
| 1 | + | 8:10,146,490:CT/C | – | 9.86E−10 | 0.07 | MSRA | Intron | eQTL, sQTLa |
| 2 | + | 6:43,288,656:T/TA | rs553448379 | 6.32E−09 | 0.07 | ZNF318 | Downstream | eQTLb |
| 3 | + | 22:40,546,041:C/CA | rs35629137 | 8.23E−09 | 0.06 | TNRC6B | Intron | eQTL |
| 4 | + | 1:103,456,996:C/CACGTGATCT | rs143424888 | 9.92E−09 | 0.06 | COL11A1 | Intron | eQTL |
| 5 | 13:99,939,901:T/C | rs7336872 | 1.10E−08 | − 0.07 | UBAC2 | Intron | – | |
| 6 | + | 14:103,057,250:C/A | rs749543 | 1.14E−08 | − 0.07 | RCOR1 | Upstream | eQTL |
| 7 | 4:88,333,667:G/T | rs115125870 | 3.59E−08 | 0.30 | NUDT9 | Upstream | – | |
| 8 | 3:44,922,141:A/C | rs1532898 | 3.73E−08 | 0.07 | TGM4 | Intron | eQTL, sQTL | |
| 9 | 17:41,952,807:G/A | rs2537 | 4.87E−08 | − 0.13 | MPP2 | 3’ UTR | eQTL |
Variant ID format: 'Chromosome:Position:Reference allele/Alternative allele’ with GRCh37 as the reference. Alternative allele was used as the effect allele in association analyses. + Previously reported loci in the context of tinnitus (See Supplemental Table 7 for details). When the variant was not listed in the GTEx panel, the most significant listed variant with p < 5 × 10–8 from that locus was used for the QTL evaluation: a8:10147398:C/T; b6:43334755:A/C. Var, variant; Gene, nearest gene; Var_pos, position of variant relative to the nearest genes; QTL, quantitative trait loci.