Table 2.

Calculated molecular properties of designed compounds by SwissADME web server.

Drug Likeness Lipinski’s rule of 5
Compound no.	MWa	MLogPb	H-bond-accc	H-bond-dond	Solubility (LogS)	TPSAe (Å)
1	245.23	0.09	5	1	− 3.75	94.30
2	349.34	1.42	6	1	− 6.58	97.38
3	383.79	1.91	6	1	− 7.17	97.38
4	417.34	1.98	9	1	− 7.41	97.38
5	435.33	2.36	10	1	− 7.67	97.38
6	417.34	1.98	9	1	− 7.41	97.38
7	385.32	2.18	8	1	− 7.11	97.38
8	367.33	1.80	7	1	− 6.84	97.38

^aMW ≤ 500, ^bMLogP ≤ 5, ^cH-bond acceptor ≤ 10, ^dH-bond donor ≤ 5, ^eTopological polar surface area.