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. Author manuscript; available in PMC: 2024 Nov 15.
Published in final edited form as: Cell Rep. 2024 Oct 10;43(10):114801. doi: 10.1016/j.celrep.2024.114801

Figure 5. A subset of molecular features that differentiate between high- and low-poly-reactivity antibodies also differentiate between paratope and non-paratope residues.

Figure 5.

Distributions of molecular features for paratope and non-paratope residues in VH and VL for 468 anti-bodies and their corresponding AUC values.

(A and B) Net charge (pH 7.4) distributions for (A) VH and (B) VL.

(C and D) Distributions of the number of isoleucine, tryptophan, and tyrosine residues for (C) VH and (D) VL.

(E and F) Distributions of the number of tryptophan, arginine, and lysine residues for (E) VH and (F) VL. AUC values with a negative sign next to them signify that the feature values are depleted in the antibody paratope or non-paratope residues.