Table 2. Multiple Linear Regression Model for 12-Month eGFR, Pooled From 20 Imputed Datasets (N = 7183)a.
| Variable | Adjusted coefficient (95% CI) | P value |
|---|---|---|
| Log2 TTD | −0.25 (−0.68 to 0.19) | .27 |
| Log2 asystolic time | −1.16 (−2.45 to 0.13) | .08 |
| Log2 nephrectomy time | 0.93 (−0.02 to 1.87) | .05 |
| Log2 cold ischemic time | −2.49 (−3.48 to −1.50) | <.001 |
| Reperfusion time, per 10 min | −0.50 (−0.92 to −0.09) | .02 |
| Received NRP | 5.60 (3.48 to 7.72) | <.001 |
| Recipient sex: female | −2.06 (−3.14 to −0.98) | <.001 |
| Recipient age, y | −0.08 (−0.13 to −0.03) | .001 |
| Recipient BMI | −0.32 (−0.44 to −0.21) | <.001 |
| Recipient ethnicity | ||
| Asian | 5.18 (3.79 to 6.57) | <.001 |
| Black | −6.11 (−7.98 to −4.25) | <.001 |
| Other | 1.46 (−2.02 to 4.94) | .41 |
| White | [Reference] | |
| Primary kidney disease | ||
| Diabetes | [Reference] | |
| Glomerulonephritis | −0.89 (−2.70 to 0.93) | .34 |
| Hypertension | −0.22 (−2.43 to 2.00) | .85 |
| Polycystic kidney disease | 0.68 (−1.28 to 2.63) | .50 |
| Pyelonephritis or reflux nephropathy | −1.82 (−4.36 to 0.72) | .16 |
| Other | −1.53 (−3.32 to 0.26) | .10 |
| Log2 recipient wait time, db | −0.55 (−0.90 to −0.21) | .002 |
| Previous kidney transplants, No. | ||
| 0 | [Reference] | |
| 1 | −1.01 (−2.73 to 0.70) | .25 |
| >1 | −7.28 (−11.42 to −3.13) | .001 |
| Donor sex: female | −1.11 (−2.18 to −0.04) | .04 |
| Donor age, y | −0.56 (−0.61 to −0.52) | <.001 |
| Donor cause of death | ||
| Hypoxic brain injury | [Reference] | |
| Ischemic stroke | −2.35 (−4.31 to −0.39) | .02 |
| Intracranial hemorrhage | −2.66 (−3.83 to −1.48) | <.001 |
| Trauma | 0.95 (−1.55 to 3.45) | .46 |
| Other | −2.79 (−4.55 to −1.03) | .002 |
| Log2 donor creatinine at retrieval | −1.99 (−2.82 to −1.16) | <.001 |
| Donor diabetes status: present | −4.90 (−6.78 to −3.01) | <.001 |
| Donor past history of drug abuse: present | 2.60 (1.12 to 4.08) | .001 |
| Donor hypertension: present | −3.55 (−4.73 to −2.37) | <.001 |
| Visual quality of perfusion | ||
| Good | [Reference] | |
| Fair | −2.78 (−4.35 to −1.21) | .001 |
| Poor | −4.69 (−7.68 to −1.70) | .002 |
| Patchy | −3.36 (−5.74 to −0.97) | .01 |
| HLA mismatch levelc | ||
| 1 | [Reference] | |
| 2 | −0.39 (−3.27 to 2.49) | .79 |
| 3 | 0.72 (−2.06 to 3.50) | .61 |
| 4 | 0.38 (−2.63 to 3.38) | .81 |
Abbreviations: BMI, body mass index; eGFR, estimated glomerular filtration rate; HLA, human leukocyte antigen; NRP, normothermic regional perfusion; TTD, time to death (withdrawal of life-sustaining treatment to mechanical asystole).
a
Right-skewed variables are log2 transformed, so the results relate to the change in 12-month eGFR every time the variable doubles. A nominal eGFR value of 10 mL/min/1.73 m2 was used for those with graft failure before 1 year.
b
Wait time from becoming active on the transplant waiting list.
c
For HLA mismatch level details, see eTable 3 in Supplement 1.