Table 4. Association of aspirin use with primary outcomes using Cox proportional-hazards model.

Outcomes	Model 1			Model 2			Model 3
	HR (95% CI)	P value		HR (95% CI)	P value		HR (95% CI)	P value
In-hospital death
Aspirin use	0.676 (0.559, 0.817)	<0.001		0.680 (0.570, 0.810)	<0.001		0.691 (0.570, 0.837)	<0.001
28-day mortality
Aspirin use	0.807 (0.681, 0.956)	0.01		0.791 (0.677, 0.923)	0.003		0.818 (0.688, 0.971)	0.02

Model 1: age, gender, renal disease, coronary artery disease, diabetes, and hypertension were adjusted; model 2: heart rate, DBP, SBP, SpO₂, glucose, hematocrit, Pt, mechanical ventilation use, and CRRT were adjusted; model 3, all covariates adjusted including age, gender, heart rate, DBP, SpO₂, glucose, hematocrit, Pt, renal disease, coronary artery disease, diabetes, hypertension, mechanical ventilation use, and CRRT. HR, hazard ratio; CI, confidence interval; DBP, diastolic blood pressure; SBP, systolic blood pressure; SpO₂, oxygen saturation; CRRT, continuous renal replacement therapy; Pt, prothrombin time.