Table 3. The method of ICG application under different conditions.

Method	Indications	Disadvantages or contraindications
CT-guided	(I) Superficial pulmonary nodules	(I) Dangerous or difficult-to-manage puncture site
	(II) Immediate surgery	(II) Multiple pulmonary nodules
	(III) Solitary pulmonary nodule	(III) Delayed surgery
		(IV) Patients with poor pain tolerance
		(V) Deep lung nodules
		(VI) Lack of hybrid operation room
VB or ENB	(I) Superficial pulmonary nodules	(I) Deep lung nodules
	(II) Immediate surgery	(II) Delayed surgery
	(III) Solitary or pulmonary multiple nodule	(III) Lack of hybrid operation room
	(IV) Dangerous or difficult-to-manage puncture site	(IV) High cost to patients
	(V) Patients with poor pain tolerance
Segmental bronchial perfusion	(I) Lung segment plane recognition	(I) Lung nodules cannot be localized
	(II) Immediate or delayed surgery	(II) Highly reliant on operator’s bronchoscopic technique
		(III) Potential risk of allergic or inflammatory reaction to the lung
Intravenous injection	(I) Superficial or deep pulmonary nodules	For nodule location:
	(II) Solitary or pulmonary multiple nodule	(I) Deep lung nodules
	(III) Lung segment plane recognition	(II) Inability to distinguish inflammatory tissue
		(III) Immediate surgery
		For segmental plane recognition:
		(I) Patients with insufficient blood supply to the lung surface
		(II) Cannot be observed on the plane being dissected

ICG, indocyanine green; CT, computed tomography; VB, virtual bronchoscopy; ENB, electromagnetic navigation bronchoscopy.