Table 2.
BDNF methylation sites and inflammatory markers according to perceived stress classification.
| Variables (n = 82) |
Perceived stress |
||||
|---|---|---|---|---|---|
| Low stress |
High to moderate stress |
Group comparisons (P value)∗ | |||
| median (IQR) | mean (±SD) | (n = 29) mean (±SD) | (n = 53) mean (±SD) | ||
| IL-6 (pg/mL) | 5.04 (2.50–6.48) | 5.09 (2.90) | 2.51 (0.13) | 6.49 (2.72) | <0.001 |
| IL-8 (pg/mL) | 5.64 (3.60–8.22) | 6.33(2.86) | 3.57 (3.60) | 7.84 (2.48) | <0.001 |
| IL-10 (pg/mL) | 8.53 (6.67–8.77) | 7.94 (1.210 | 8.18 (0.91) | 7.93 (1.01) | 0.329 |
| IL-12p70 (pg/mL) | 2.00 (1.90–4.31) | 3.32 (2.07) | 2.10 (0.38) | 3.98 (2.31) | <0.001 |
| BDNF - CpG5 (%) | 4.64 (3.15–3.67) | 4.57 (3.07) | 4.81 (3.66) | 4.46 (2.66) | 0.802 |
| BDNF - CpG6 (%) | 3.60 (2.21–5.13) | 3.87 (2.63) | 4.13 (3.11) | 3.73 (2.32) | 0.623 |
| BDNF - CpG7 (%) | 5.08 (3.98–6.68) | 5.11 (2.83) | 5.07 (3.57) | 5.12 (2.36) | 0.888 |
| BDNF - CpG8 (%) | 4.20 (2.90–6.44) | 4.84 (4.87) | 5.19 (6.96) | 4.73 (3.19) | 0.595 |
| BDNF - CpG9 (%) | 11.26 (9.39–13.87) | 11.59 (5.32) | 10.91 (4.13) | 11.85 (6.08) | 0.956 |
| BDNF - CpG10 (%) | 1.51 (0–2.88) | 1.45 (1.76) | 1.55 (1.78) | 1.48 (1.79) | 0.824 |
| BDNF - CpG11 (%) | 6.28 (4.93–8.14) | 6.47 (2.69) | 6.65 (2.95) | 6.30 (2.70) | 0.512 |
| BDNF - CpG12 (%) | 3.48 (0–4.96) | 3.36 (3.44) | 3.31 (2.67) | 3.40 (3.83 | 0.697 |
| BDNF - CpG13 (%) | 4.1 (2.86–6.03) | 4.07 (2.84) | 3.72 (2.83) | 4.35 (2.81) | 0.474 |
Notes: Median with interquartile range (IQR), means with standard deviations (SD), ∗non-parametric Kruskal-Wallis’ test. BDNF-CpG: methylation of CpG sites of brain-derived neurotrophic factor gene.