Table 4.

The effects of BDNF-CpGs by Inflammatory markers.

GzLM models - Inflamatory markers
	β	SE	95% CI		Wald ꭓ2	P-value	P-value adja
			Min	Max
IL-6 (pg/mL)versus %DNA methylation (BDNF - CpGs)
CpG5	0.235	0.119	0.001	0.468	3.887	0.049	0.243
CpG6	−0.031	0.026	−0.082	0.019	1.498	0.221	0.473
CpG7	−0.028	0.024	−0.075	0.018	1.406	0.236	0.393
CpG8	−0.009	0.014	−0.036	0.018	0.450	0.502	0.685
CpG9	−0.005	0.019	−0.042	0.032	0.071	0.790	0.911
CpG10	0.006	0.036	−0.064	0.077	0.032	0.858	0.919
CpG11	−0.004	0.024	−0.051	0.044	0.023	0.879	0.879
CpG12	−0.027	0.030	−0.085	0.031	0.828	0.363	0.544
CpG13	0.051	0.027	−0.001	0.103	3.640	0.056	0.211
IL-8 (pg/mL)versus%DNA methylation (BDNF - CpGs)
CpG5	−0.022	0.018	−0.058	0.014	1.424	0.233	0.436
CpG6	−0.034	0.022	−0.077	0.009	2.348	0.125	0.471
CpG7	−0.020	0.020	−0.059	0.019	0.982	0.322	0.439
CpG8	0.006	0.011	−0.015	0.027	0.330	0.566	0.707
CpG9	0.019	0.015	−0.009	0.048	1.741	0.187	0.467
CpG10	0.031	0.029	−0.026	0.089	1.142	0.285	0.428
CpG11	−0.030	0.019	−0.068	0.008	2.341	0.126	0.378
CpG12	−0.028	0.023	−0.074	0.018	1.436	0.231	0.495
CpG13	0.047	0.021	0.005	0.089	4.869	0.027	0.205
IL-10 (pg/mL)versus%DNA methylation (BDNF - CpGs)
CpG5	−0.009	0.005	−0.019	0.002	2.732	0.098	0.239
CpG6	0.004	0.006	−0.007	0.016	0.585	0.444	0.581
CpG7	0.008	0.006	−0.003	0.018	1.822	0.177	0.301
CpG8	−0.002	0.003	−0.007	0.004	0.413	0.520	0.590
CpG9	0.003	0.004	−0.005	0.010	0.433	0.510	0.620
CpG10	−0.001	0.026	−0.052	0.050	0.002	0.962	1.000
CpG11	−0.093	0.030	−0.152	−0.033	9.341	0.002	0.010
CpG12	0.000	0.006	−0.012	0.012	0.000	0.995	0.995
CpG13	−0.007	0.006	−0.018	0.005	1.224	0.269	0.380
IL-12p70 (pg/mL)versus%DNA methylation (BDNF - CpGs)
CpG5	0.287	0.113	0.066	0.508	6.492	0.011	0.022
CpG6	0.027	0.071	−0.113	0.167	0.142	0.707	0.707
CpG7	−0.263	0.077	−0.415	−0.112	11.576	0.001	0.005
CpG8	0.089	0.048	−0.004	0.183	3.512	0.061	0.077
CpG9	−0.274	0.122	−0.513	−0.035	5.031	0.025	0.040
CpG10	0.057	0.036	−0.014	0.128	2.494	0.114	0.137
CpG11	−0.455	0.145	−0.739	−0.171	9.867	0.002	0.006
CpG12	0.051	0.058	−0.063	0.165	0.766	0.382	0.398
CpG13	0.514	0.138	0.244	0.784	13.918	0.000	0.005

Note: Generalized linear models obtained with Gamma distribution. P-values were presented based on Wald's chi-square test (Wald ꭓ2) and were adjusted by FDR (False Discovery Rate). P < 0.05 (IC = 95%); CpG: DNA methylation sites of BDNF.

^aFDR: False Dicovery Rate.