Figure 15.
Representative examples that show in vitro model of aneurysm
(A) A full-scale PDMS phantom model replicates the anterior cerebral arterial network, with the model’s surface capable of being depressed by a thumb to simulate effects on the vasculature. Copyright 2022, Nature Publishing Group, Reproduced with permission.244
(B) The schematic diagram of AIV, microscopic images from the microfluidic platform showing a microaneurysm on a chip, and 3D predictions of the AIV in the microaneurysm channel with a branching number ratio of 5 collectively illustrate the visual presentation of this study. Copyright 2021, National Academy of Sciences, Reproduced with permission.245
(C) An in vitro human IA model is fabricated using a modified liquid-assisted injection molding approach, resulting in cellularized IA models for study. Copyright 2021, Elsevier BV, Reproduced with permission.246
(D) The in vitro aneurysm vessel structure undergoes perfusion, followed by the endothelialization of the printed vessels containing aneurysms, and is monitored through brightfield micrographs during the insertion of bare platinum coil via an endovascular microcatheter (scale bar ii: 2 mm). Copyright 2019, John Wiley & Sons, Reproduced with permission.247