REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
CD115 APC	eBioscience	#17-1152-80
CD11 b PE	BD Pharmingen	#557397
CD19 PE-Cy7	eBioscience	#25-0193-81
Ly6G BV421	BioLegend	#127628
Biotin-conjugated cKit antibody	BioLegend	#105803
Anti-biotin magnetic beads	Miltenyi Biotec	#130-090-485
CD117 (cKit) PE-Cy7	eBioscience	#25-1171-82
Streptavidin PECy-7	BioLegend	#405206
Ly6A/E (Sca-1) PE	BD Pharmingen	#553336
CD3e APC (Lineage cocktail)	BD Pharmingen	#553066
Ly6C/Ly6G APC (Lineage cocktail)	BD Pharmingen	#553129
CD11b APC (Lineage cocktail)	BD Pharmingen	#553312
Ter119 APC (Lineage cocktail)	BioLegend	#116211
B220 APC (Lineage cocktail)	BD Pharmingen	#553092
CD11c APC (Lineage cocktail)	BD Pharmingen	#550261
CD5 APC (Lineage cocktail)	eBioscience	#17-0051-82
CD115 APC (Lineage cocktail)	BioLegend	#135509
CD16/32 PE	BD Pharmingen	#561727
CD117 (cKit) PE-Cy7	eBioscience	#25-1171-82
CD34 Alexa Fluor 647	BioLegend	#152205
Ly-6G Alexa Fluor 700	BioLegend	#127621
Ly-6C APC-Cy7	BioLegend	#128025
F4/80 Pacific Blue	BioLegend	#123123
CD115 Brilliant Violet 605	BioLegend	#135517
CD11b Brilliant Violet 711	BioLegend	#101241
CD11c PerCP-Cy5.5	BioLegend	#117327
anti-WDR5	Abcam	#ab56919
anti-mouse HRP	Invitrogen	#31431
Bacterial and virus strains
E. coli T7 Express cells	NEB	#C2566H
Platinum-E Retroviral Packaging Cell Lines	N/A	N/A
Chemicals, peptides, and recombinant proteins
Polybrene	Sigma	#TR-1003-G
Polyethylenimine	Polysciences	#24765-2
Red blood cell lysis solution	Miltenyi	#130-094-183
Methocult MC3434	STEMCELL Technology	#03444
WST-1 reagent	Roche	#05015944001
HisTrap FF crude column	Cytiva	#17528601
Superdex 200 prep grade column	XK 26 × 60, Cytiva	# 28-9893-36
RNAeasy Kit	Qiagen	#74104
mIL-3	STEMCELL Technology	#78042.1
mIL-6	STEMCELL Technology	#78052.2
mSCF	STEMCELL Technology	#78064.1
Critical commercial assays
QuikChange Site-Directed Mutagenesis Kit	Stratagene	#200518
CellTrace Violet	ThermoFisher Scientific	#C34557
NextSeq500 platform	Illumina, EMBL Genomics Core Facility	N/A
Deposited data
Raw and analyzed RNAseq data	This study	GEO: GSE266544
Experimental models: Cell lines
v-Abl transformed CebpaΔ/ΔCebpbΔ/Δ pre-B cells	Cirovic et al., 201718	N/A
Bone marrow derived Cebpafl/flCebpbfl/fl cells	This study	N/A
HEKT-293 cells	This study	N/A
Oligonucleotides
See Table S1	This study	N/A
Recombinant DNA
pMSCV-IRES-EGFP (MIEG) retroviral vectors	Cirovic et al. 201718	N/A
pRARE2 plasmid	Novagen	N/A
Software and algorithms
FlowjoTM	FlowJo, LLC	V8
EVOSTM FLTM auto imaging system	Thermo Fisher Scientific	N/A