Table 1.
Key Pathways and Functions Associated with common DEGs in UCEC.
| Category | Term | Count | P-Value |
|---|---|---|---|
| GOTERM_BP_DIRECT | GO:0007155∼cell adhesion | 29 | 2.50047673243061E-09 |
| GO:0098609∼cell-cell adhesion | 14 | 2.64417934956445E-06 | |
| GO:0001822∼kidney development | 11 | 5.48734211365512E-06 | |
| GO:0051045∼negative regulation of membrane protein ectodomain proteolysis | 4 | 1.34084356187903E-04 | |
| GO:0009410∼response to xenobiotic stimulus | 13 | 1.76766742340566E-04 | |
| GO:1905821∼positive regulation of chromosome condensation | 4 | 1.99096026233E-04 | |
| GO:0070301∼cellular response to hydrogen peroxide | 7 | 3.04681102931167E-04 | |
| GO:0006958∼complement activation, classical pathway | 6 | 3.21529176670062E-04 | |
| GO:1905820∼positive regulation of chromosome separation | 4 | 3.83232519690081E-04 | |
| GO:0007179∼TGF-β receptor signaling pathway | 8 | 4.44801551827947E-04 | |
| GOTERM_CC_DIRECT | GO:0005615∼extracellular space | 58 | 5.86107640404059E-09 |
| GO:0009986∼cell surface | 30 | 1.0171692546024E-08 | |
| GO:0005604∼basement membrane | 12 | 2.98877922127083E-08 | |
| GO:0070062∼extracellular exosome | 61 | 7.56643484002605E-08 | |
| GO:0005576∼extracellular region | 59 | 1.44986831200153E-07 | |
| GO:0031012∼ECM | 16 | 2.084009175593E-07 | |
| GO:0005923∼bicellular tight junction | 12 | 1.30844323237061E-06 | |
| GO:0000796∼condensin complex | 4 | 1.82364694518497E-04 | |
| GO:0016323∼basolateral plasma membrane | 13 | 2.01626271798142E-04 | |
| GO:0005788∼endoplasmic reticulum lumen | 14 | 2.70688421114552E-04 | |
| GOTERM_MF_DIRECT | GO:0005201∼ECM structural constituent | 16 | 1.20195745984562E-10 |
| GO:0005178∼integrin binding | 14 | 3.74883032599999E-07 | |
| GO:0001540∼beta-amyloid binding | 8 | 2.32896641310804E-04 | |
| GO:0005515∼protein binding | 206 | 4.0525758357468E-04 | |
| GO:0005509∼calcium ion binding | 23 | 9.74217058006634E-04 | |
| GO:0003779∼actin binding | 14 | 0.001161556 | |
| GO:0030021∼ECM structural constituent conferring compression resistance | 4 | 0.001365846 | |
| GO:0030169∼low-density lipoprotein particle binding | 4 | 0.001641286 | |
| GO:0005518∼collagen binding | 6 | 0.002252549 | |
| GO:0042802∼identical protein binding | 40 | 0.002508921 | |
| KEGG_PATHWAY | hsa04512:ECM-receptor interaction | 12 | 4.34912468830043E-07 |
| hsa05165:Human papillomavirus infection | 19 | 2.20129454422999E-05 | |
| hsa04514:Cell adhesion molecules | 11 | 4.72510022129723E-04 | |
| hsa04610:Complement and coagulation cascades | 8 | 8.12810102643477E-04 | |
| hsa04510:Focal adhesion | 12 | 9.63344216555539E-04 | |
| hsa04151:PI3K-Akt signaling pathway | 15 | 0.004668709 | |
| hsa04145:Phagosome | 9 | 0.005637821 | |
| hsa04530:Tight junction | 9 | 0.010791298 | |
| hsa04350:TGF-beta signaling pathway | 7 | 0.012397517 | |
| hsa04670:Leukocyte transendothelial migration | 7 | 0.016487686 |