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. 2024 Oct 31;124(21):12242–12263. doi: 10.1021/acs.chemrev.4c00438

Table 1. List of Software Tools and Methods Reviewed in This Papera.

Software Access to Raw Data
    
  Automated Peptide Search (section 4.1) Multimodal Analysis (section 4.2) Differential Analysis (section 4.3) High Resolution HDX-MS (section 4.4)
Claesen et al.31     +  
DECA32     + +
deMix33 + +    
Deuteros 2.034     +  
ExMS235,36 + +   +
ExPfact37,38       +
HaDeX39     +  
HD-eXplosion40     +  
HX-Express41 + +    
Hdflex42     + +
HDXAnalyzer43     +  
HDXModeller44       +
Hdxstats45     + +
HDX-Workbench(27) + + + +
HR-HDXMS46       +
Mass Spec Studio47−50 + + +  
MEMHDX51     +  
Protein Metric (Dotmatics) + + + +
PyHDX52       +
ReX53     + +
Saltzberg et al.54       +
a

An updated list of software, publications and other resources for HDX-MS data analysis is available at the following link: https://github.com/hadexversum/HDX-MS-resources. Commercial software are shown in italic.