. 2024 Oct 31;124(21):12242–12263. doi: 10.1021/acs.chemrev.4c00438

Table 3. List of Software Packages for High-Resolution HDX-MS Data Analysis at the Peptide Level.

High Resolution HDX-MS
Name	Strategy
DECA³²	overlapping peptide segmentation
HDflex⁴²	stretched exponential
Hdxstats⁴⁵	stretched exponential
ExMS2^35,36	isotopic envelope fitting
ExPfact^37,38	intensity-weighted average fitting
pyHDX⁵²	intensity-weighted average fitting
HDXModeller⁴⁴	intensity-weighted average fitting
Saltzberg et al.⁵⁴	intensity-weighted average fitting
HR-HDXMS⁴⁶	intensity-weighted average fitting
ReX⁵³	change-point model