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. 2024 Nov 14;46(2):2427158. doi: 10.1080/0886022X.2024.2427158

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© 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 9. — The expression levels of DPEP1, ACADM, CYP4A11 and SLC22A5 were reduced in patients with IgAN and in human mesangial cells (HMCs). (A) the mRNA expression of key genes was verified through qRT-PCR in peripheral blood samples from IgAN patients (n = 25) compared to a healthy control group (n = 25); **p < 0.001, ***p < 0.0001; (B) In HMCs stimulated with Gd-IgA1 (1 mg/ml for 24h), the mRNA expression levels of these key genes were lower when compared to the control group. n = 5, **p < 0.001, ***p < 0.0001.