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[Preprint]. 2024 Nov 3:2024.10.29.620896. [Version 1] doi: 10.1101/2024.10.29.620896

Fig. 7. AKT activity is reduced in the aorta of LmnaG609G/+ mice.

Fig. 7.

A. Western blot comparing the levels of phosphorylated AKT at serine-473 (p-AKT-S473) in aortas from young and old Lmna+/+, LmnaG609G/+, and Zmpste24−/− mice. Actin was measured as a loading control. The ages and mouse IDs are shown above each sample. B. Bar graph shows the levels of total AKT (relative to actin) in young and old Lmna+/+, LmnaG609G/+, and Zmpste24−/− mice. Mean ± SEM (n = 4 mice/group). ANOVA. ns, not significant. C. Bar graph shows the levels of p-AKT-S473 (relative to actin) in young and old Lmna+/+, LmnaG609G/+, and Zmpste24−/− mice. Mean ± SEM (n = 4 mice/group). ANOVA. *, P < 0.05. **, P < 0.01. D. Bar graph shows the levels of p-AKT-S473 (relative to total AKT) in young and old Lmna+/+, LmnaG609G/+, and Zmpste24−/− mice. Mean ± SEM (n = 4 mice/group). ANOVA. *, P < 0.05. **, P < 0.01.