Fig. 2.

α-syn deficiency induced olfaction impairment and aberrant projection of olfactory neurons. A Statistical results of buried food pellet test. Data are expressed as the mean ± SEM.**p < 0.01, n = 10. B Statistical results of two-bottle preference test. Data are expressed as the mean ± SEM. **p < 0.01, n = 10. C Immunofluorescence staining using an antibody against the Olfr1507 revealed that Olfr1507-expressing OSNs axon fibers converge to one specific glomerulus in each half bulb in wild type mice(WT, α-Syn^+/+) as indicated by the white arrow. In α-syn null mice (KO, α-Syn^−/−), Olfr1507 -expressing OSNs axons projected aberrantly. Some Olfr1507 positive axons projected to external plexiform layer as indicated by the white arrowhead. Some projected to the inner plexiform layer as indicated by the yellow arrowhead. And some projected out of the glomerulus although it still locates in the glomerulus layer as indicated by the green arrowhead