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. 2024 Nov 14;14:139. doi: 10.1186/s13578-024-01313-6

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Identification of differentially expressed proteins in α-syn null mice by iTRAQ based LC–MS. A Flow chart for differentially expressed proteins identification. B, C Genotyping and western blotting to confirm the mice genotype. D The heatmap for the differentially expressed proteins. In the heatmap, red color represents up-regulated differentially expressed proteins and the green color represents down-regulated differentially expressed proteins. E statistical summary for differentially expressed proteins. A total of 188 proteins, can be seen in the figure in the difference comparison group. There are 133 pcs of up-regulation (red) of the protein and 55 pcs of down-regulation (green) of the protein. F All the differences in protein GO enrichment (BP, CC, MF) and pathway KEGG enrichment results and significant (p < 0.05) number were summarized. The blue column represents the total number of enrichment, orange column represents a significant number of enrichment. A protein is usually involved in a number of functions or pathways, so the total number of GO enrichment and pathway KEGG enrichment results will be far greater than the number of differentially expressed proteins. The significant function or the pathway means that the difference of the enrichment to the function or the pathway is significant