Table 3.

Comparison of Organic, Inorganic, and Organic-Inorganic Hybrid Sonosensitizers

Category	Organic Sonosensitizers	Inorganic Sonosensitizers	Organic-Inorganic Hybrid Sonosensitizers
ROS Generation Capacity	Moderate (limited ROS generation)	High (strong ROS generation from metal nanoparticles)	High (enhanced ROS from combined organic-inorganic components)
Biocompatibility	High (derived from natural molecules, low toxicity)	Moderate (metal-based nanoparticles, potential toxicity)	High (improved biocompatibility due to organic component)
Stability	Low (rapid degradation, poor stability in vivo)	High (chemically stable, slow degradation in the body)	High (enhanced stability from inorganic components)
System Design Flexibility	Limited (difficult to modify structure)	High (wide range of inorganic nanoparticle designs)	High (flexible design, enhanced functionality through combination)
Toxicity	Low (derived from natural materials, low systemic toxicity)	Moderate (potential toxic by some metal nanoparticles)	Moderate (toxicity from inorganic part, mitigated by organic component)