Table 1.

Comparison of imaging parameters between NIR and SWIR imaging systems, split into penile cancer and head and neck cancer.

Parameter	NIR	SWIR	P-value	NIR	SWIR	$P$ value
	Penile cancer			Head and neck cancer
TBR whole tissue slice	1.43 (1.15 to 1.80)	1.25 (1.21 to 1.35)	0.0359*	2.20 (1.95 to 2.61)	0.99 (0.98 to 1.03)	0.0625
aCNR whole tissue slice	0.60 (0.18 to 1.05)	0.86 (0.53 to 1.07)	0.106	1.38 (1.07 to 2.00)	–0.01 (–0.04 to 0.06)	0.0625
Median tumor fluorescence intensity (IQR) (A.U.)	0.0085 (0.021)	4189.5 (2696.5)		0.0158 (0.008)	5661 (2478)
Median background fluorescence intensity (IQR) (A.U.)	0.0059 (0.013)	3331.3 (1937.8)		0.0073 (0.005)	5635.8 (2602.5)
TBR over line	1.24 (1.07 to 1.47)	1.28 (1.17 to 1.38)	0.92	1.47 (1.34 to 1.57)	1.02 (0.79 to 1.11)	<0.0001*
aCNR over line	0.63 (0.10 to 1.09)	1.06 (0.60 to 1.45)	<0.0001*	1.42 (1.08 to 2.04)	0.06 (–0.22 to 0.27)	<0.0001*
AUC aCNR	2.56 (1.34 to 6.85)	4.81 (2.30 to 8.48)	0.0003*	17.81 (2.79 to 27.4)	1.09 (0.24 to 4.10)	<0.0001*
Absolute distance tumor border to aCNR=1 (mm)	0.33 (0.10 to 0.62)	0.53 (0.16 to 0.87)	0.0076*	0.19 (0.06 to 0.41)	1.02 (0.57 to 1.80)	0.0043*
Overlap pixels tumor/background (%)	62.5 (36.9 to 92.9)	44.0 (22.3 to 75.7)	0.0001*	32.0 (9.25 to 49.0)	100 (84.5 to 100)	<0.0001*

Abbreviations: tumor-to-background ratio (TBR), adapted contrast-to-noise ratio (aCNR), area under the curve (AUC).