Fig. 7.

Driver mutation timing estimates in ovarian clear cell carcinoma specimens. A Based on the timing of somatic mutations relative to somatic copy number change at the same locus, we categorized clonal mutation events as “early clonal” (occurring before the copy-number gain), “untimed clonal” (inability to determine the timing relative to the somatic copy-number gain), and “late clonal” (occurring after the somatic-copy-number gain). B Driver genes were grouped according to the timing and clonality of the identified somatic mutations. Color bars to the right of each gene symbol indicate the proportions of early clonal (dark blue), untimed clonal (light blue), late clonal (orange), and subclonal (dark orange) mutations for each gene. The values displayed to the right of the bar graph indicate the number of clonal mutations and the total mutation count within each specified gene. Genes categorized as “early clonal” are identified as potential key factors in the initiation of OCCC