Table 2.
EGFR expression features in OC patients (420 cases)
| Characteristics | N (%) | EGFR expression [N (%)] | χ2 | p value | |
|---|---|---|---|---|---|
| Low (H-score ≤ 96.83) | High (H-score > 96.83) | ||||
| Age at diagnosis (years) | 2.089 | 0.148 | |||
| ≤ 50 | 149 (35.5) | 80(53.7) | 69(46.3) | ||
| > 50 | 269 (64.0) | 164(61.0) | 105(39.0) | ||
| Unknown | 2 (0.5) | ||||
| Menopause | 0.954 | 0.329 | |||
| No | 150 (35.7) | 84(56.0) | 66(44.0) | ||
| Yes | 256 (61.0) | 156(60.9) | 100(39.1) | ||
| Unknown | 14 (3.3) | ||||
| Histological subtypes | 7.106 | 0.008* | |||
| Serous | 371 (88.3) | 209 (56.3) | 162 (43.7) | ||
| Nonserous | 44 (10.5) | 34 (77.3) | 10 ((22.7) | ||
| Unknown | 5 (1.2) | ||||
| FIGO stage | 2.706 | 0.439 | |||
| I | 43 (10.2) | 22 (51.2) | 21 (48.8) | ||
| II | 34 (8.1) | 23 (67.6) | 11 (32.4) | ||
| III | 291 (69.3) | 172 (59.1) | 119 (40.9) | ||
| IV | 18 (4.3) | 9 (50.0) | 9 (50.0) | ||
| Unknown | 34 (8.1) | ||||
| Histological grade | 13.344 | 0.001* | |||
| Grade 1 | 24 (5.8) | 6 (25.0) | 18 (75.0) | ||
| Grade 2 | 17 (4.0) | 13 (76.5) | 4 (23.5) | ||
| Grade 3 | 332 (79.0) | 197(59.3) | 135 (40.7) | ||
| Unknown | 47 (11.2) | ||||
| Lymph node metastasis | 0.106 | 0.744 | |||
| Negtive | 136 (32.4) | 81(59.6) | 55(40.4) | ||
| Positive | 76 (18.1) | 47(61.8) | 29(38.2) | ||
| Unknown | 208 (49.5) | ||||
| Ascites (mL) | 1.503 | 0.220 | |||
| < 500 | 87 (20.7) | 46 (52.9) | 41(47.1) | ||
| ≥ 500 | 213 (50.7) | 129 (60.6) | 84(39.4) | ||
| Unknown | 120 (28.6) | ||||
| Preoperative CA125 (U/ml) | |||||
| < 35 | 28 (6.7) | 17(60.7) | 11(39.3) | 0.091 | 0.763 |
| ≥ 35 | 372 (88.5) | 215(57.8) | 157(42.2) | ||
| Unknown | 20 (4.8) | ||||
| Residual tumor size (cm) | |||||
| ≤ 1 | 137 (32.6) | 67(48.9) | 70(51.1) | 14.266 | 0.000* |
| > 1 | 59 (14.1) | 46(78.0) | 13(22.0) | ||
| Unknown | 224 (53.3) | ||||
| Platinum resistance | |||||
| No | 91 (21.7) | 44(48.4) | 47(51.6) | 0.782 | 0.377 |
| Yes | 35 (8.3) | 20(57.1) | 15(42.9) | ||
| Unknown | 294 (70.0) | ||||
| Relapse | |||||
| No | 123 (29.3) | 50 (40.7) | 73 (59.3) | 15.991 | 0.000* |
| Yes | 141 (33.6) | 92 (65.2) | 49 (34.8) | ||
| Unknown | 156 (37.1) | ||||
| Death | 9.151 | 0.002* | |||
| No | 182 (43.3) | 94(51.6) | 88(48.4) | ||
| Yes | 142 (33.8) | 97(68.3) | 45(31.7) | ||
| Unknown | 96 (22.9) | ||||
*p < 0.05. OC, ovarian cancer; FIGO, International Federation of Gynecology and Obstetrics; CA125, cancer antigen 125