Table 3.
Clinical outcomes of patients with blood purification or medical treatment after propensity score matching or inverse probability weighting
| Clinical outcomes | After PSM | After IPTW | ||||||
|---|---|---|---|---|---|---|---|---|
| Blood purification (n = 63) | Conventional treatment (n = 63) | Difference (95% CI) | p | Blood purification (n = 282) | Conventional treatment (n = 310) | Difference (95% CI) | p | |
| Primary outcome | ||||||||
| OFFD, median (IQR), days | 12 (7, 14) | 13 (11, 14) | − 1 (− 2, 0) | 0·0040 | 13 (8, 14) | 14 (11, 14) | − 1 (− 1, 0) | < 0·001 |
| Secondary outcomes | ||||||||
| Composite outcome, n (%) | 13 (20·6) | 2 (3·2) | 0·174 (0·065, 0·283) | 0·0070 | 56 (19·9) | 9 (2·9) | 0·170 (0·120, 0·220) | < 0·001 |
| ICU-free day to day 14, median (IQR), days | 9 (3, 11) | 14·0 (9, 14) | − 4 (− 5, − 3) | < 0·001 | 9 (4, 11) | 14 (10, 14) | − 4 (− 4, − 3) | < 0·001 |
| Hospital-free day to day 14, median (IQR), days | 0 (0, 6) | 5 (2, 7) | − 2 (− 4, − 0·5) | 0·0010 | 3 (0, 7) | 6 (2, 7) | − 1 (− 2, − 0·5) | < 0·001 |
| Hospital-free day to day 28, median (IQR), days | 14 (7, 20) | 19 (16, 21) | − 4 (− 7, − 2) | < 0·001 | 17 (9, 21) | 20 (16, 21) | − 2·5 (− 4, − 1) | < 0·001 |
| Hospital-free day to day 60, median (IQR), days | 46 (39, 52) | 51 (48, 53) | − 4 (− 7, − 2) | < 0·001 | 49 (41, 53) | 52 (48, 53) | − 3 (− 4, − 2) | < 0·001 |
| SOFA rank to day 14, median (IQR) | − 11 (− 26, 2) | − 19 (− 36, 0) | 7·0 (0, 15) | 0·022 | − 10 (− 22, 2) | − 12 (− 28, 1) | 4 (1, 8) | 0·0020 |
| ΔSOFA max to day 14, median (IQR) | 2 (0, 3) | 0 (− 1, 2) | 1 (0, 2) | 0·020 | 1 (0, 3) | 1 (0, 2) | 1 (1, 1) | < 0·001 |
| ΔSOFA14 to day 14, median (IQR) | − 2 (− 3, 0) | − 2 (− 3, 0) | 0 (0, 1) | 0·30 | − 2 (− 2, 0) | − 1 (− 3, 0) | 0 | 0·39 |
| 60-day mortality, n (%) | 2 (3·2) | 0 | 0·032 (− 0·011, 0·075) | 0·50 | 16 (5·7) | 0 | 0·057 (0·030, 0·084) | < 0·001 |
| 60-day IPN, n (%) | 4 (6·3) | 0 | 0·063 (0, 0·12) | 0·13 | 18 (6·4) | 4 (1·3) | 0·051 (0·020, 0·082) | 0·0020 |
| ICU requirement during index admission, n (%) | 59 (93·7) | 24 (38·1) | 0·556 (0·422, 0·690) | < 0·001 | 258 (91·8) | 80 (25·8) | 0·660 (0·602, 0·718) | < 0·001 |
| New-onset organ failure to day 14, n (%) | ||||||||
| Respiratory | 20 (31·7) | 13 (20·6) | 0·111 (− 0·041, 0·263) | 0·25 | 84 (29·8) | 80 (25·8) | 0·040 (− 0·032, 0·112) | 0·31 |
| Renal | 5 (7·9) | 5 (7·9) | 0 | 1·0 | 16 (5·7) | 30 (9·6) | − 0·039 (− 0·082, 0·004) | 0·090 |
| Cardiovascular | 6 (9·5) | 4 (6·3) | 0·032 (− 0·062, 0·126) | 0·73 | 31 (11·0) | 14 (4·5) | 0·065 (0·022, 0·108) | 0·0030 |
TG triglyceride, OFFD organ failure-free days to day 14, Composite outcome a composite of death from any cause by day 28 and the presence of at least one organ failure at day 7, ICU intensive care unit, SOFA sequential organ failure assessment, IPN infected pancreatic necrosis