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. 2024 Nov 15;23:255. doi: 10.1186/s12943-024-02130-8

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 7 — (a) Synthesis of ultrathin Mn-based LDH nanosheets and subsequent loading of IFN-γ via electrostatic interactions. (b) Immune cell death induced by ferroptosis and subsequent DC maturation. (c-d) The amount of ATP released by 4T1 cells. (e-f) Quantification of 4T1 cell surface calreticulin (CRT) exposure. (g-h) Quantitative examination of HMGB1 release in cancer cell nuclei. (i-j) Quantification of bone marrow-derived DC (BMDC) maturity after 24 h of culture in different tumor cell groups. (k) Schematic of uMn-LDH-induced DC maturation. (l-m) Quantitative analysis of mature BMDCs incubated with various formulations. (n) Schematic of uMn-LDHs inducing macrophage polarization from M2 to M1. (o-p) Mean fluorescence intensity ratios of CD80 to CD206 on CD11b⁺ F4/80⁺ BMDMs after the indicated treatments [192]