Table 3.

List of the NMD approved by FDA for marketing through the PMA process. Extracted from Premarket Approval (PMA) database https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfpma/pma.cfm (keyword: nano)

Medical application/specialty	Device/trade name	Applicant	Decision date	Withdrawal date	Nanomaterial	Indication
Cardiovascular	Cobra PzF NanoCoated Coronary Stent System	Celonova Biosciences, Inc.	02/21/2017 etc.*	12/22/2022	Polyphosphazene nanocoating	Coronary stent system for improving coronary luminal diameter in patients, including those with diabetes mellitus, with symptomatic ischemic heart disease from de novo lesions in native coronary arteries

^*Disc.: Due to the complex regulatory process and need for continuous improvement, medical devices often undergo multiple revisions and approvals, resulting in several decision dates throughout their life cycle