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. 2024 Nov 14;19:116. doi: 10.1186/s13062-024-00564-0

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 4 — 20-gene TMB and DNAH5 mutation prognostic role. (a) Kaplan–Meier curves showing the effect of 20-gene TMB on OS in the combined CRC cohort. (b) The effect of 20-gene TMB on PFS in the combined CRC cohort. (c) Density plots of the TMB high-sample and TMB low-sample distributions and the corresponding cut points. (d) Forest plot summarizing prognostic impact of 20-gene TMB on OS by multivariable Cox regression. (e) Forest plot summarizing prognostic impact of 20-gene TMB on PFS by multivariable Cox regression. (f) The forest plot shows the results of multivariable Cox regression in patients with high TMB. (g) OS in groups TMB^low, TMB^high DNAH5^wild and TMB^high DNAH5^mut. (h) PFS in groups TMB^low, TMB^high DNAH5^wild and TMB^high DNAH5^mut