Table 2. Genomic loci showing genome-wide significant main or interaction effects with ME on brain GMVs.

SNPs with significant main or interaction effects were clumped using PLINK, and only those with the smallest P values in each locus are shown in the table. The position of SNP was built upon GRCh38. BETA indicates the effect of each SNP on regional GMV among participants with high, medium, and low levels of ME. As ME was treated as a continuous variable, the genetic effects were estimated using a horizontal shift of ME. MAF, minor allele frequency.

Phenotype	SNP (Chr:BP)	Allele	MAF	High-ME		Medium-ME		Low-ME		G×ME effect
				BETA	P	BETA	P	BETA	P	BETA	P
Cuneus	rs7372321 (3:64728139)	C/T	0.09	0.10	0.001	−0.28	1.07 × 10−5	−0.65	1.84 × 10−7	0.38	9.22 × 10−9
Lateral orbitofrontal	rs57466991 (8:41762594)	A/G	0.17	0.03	0.112	−0.20	2.29 × 10−7	−0.42	2.05 × 10−8	0.22	1.02 × 10−8
Lingual	rs35179353 (21:19854073)	C/T	0.11	0.06	0.016	−0.27	1.13 × 10−6	−0.59	5.27 × 10−8	0.32	9.14 × 10−9
Middle temporal	rs964508578 (8:9081668)	C/T	0.53	0.03	0.018	−0.13	3.81 × 10−7	−0.29	2.13 × 10−9	0.16	1.68 × 10−10
	rs1493536 (11:129307277)	C/T	0.44	0.00	0.897	0.14	8.71 × 10−9	0.29	5.42 × 10−9	−0.14	3.87 × 10−8
Brain stem	rs55829244 (9:9533520)	T/G	0.12	0.02	0.310	−0.22	4.91 × 10−8	−0.46	1.01 × 10−8	0.24	1.10 × 10−8
Cortex	rs1423687 (5:39103314)	A/G	0.35	1.2 × 10−3	0.913	0.12	1.11 × 10−8	0.23	7.18 × 10−9	−0.12	5.21 × 10−8
	rs12411861 (10:95539609)	G/A	0.18	−3.0 × 10−3	0.824	0.12	2.36 × 10−8	0.25	7.56 × 10−9	−0.13	4.62 × 10−8
	rs3964317 (16:65497034)	A/G	0.38	−0.02	0.164	0.10	2.48 × 10−7	0.22	1.50 × 10−8	−0.12	1.03 × 10−8
	rs73922613 (19:13549883)	A/G	0.05	0.01	0.617	−0.28	1.68 × 10−8	−0.57	5.54 × 10−9	0.29	1.26 × 10−8
	rs2081046 (19:33262430)	T/C	0.28	−0.04	0.003	0.10	6.27 × 10−7	0.23	9.34 × 10−10	−0.13	2.87 × 10−11