Table 1.
Hazard ratios for incidence of SARS-CoV-2 across participant characteristics including 11,154 participants of the REDUCE study with complete data on all characteristics
| Characteristic | Entire follow-upa |
Period 1: until November 2021b |
Period 2: from December 2021b |
|||
|---|---|---|---|---|---|---|
| HR (95% CI) | P- value | HR (95% CI) | P- value | HR (95% CI) | P- value | |
| Age - per 10 years younger | ||||||
| March 2021 – May 2022c | 1.20 (1.15–1.26) | <0.001 | 1.08 (0.91–1.28) | 0.357 | 1.21 (1.16–1.27) | <0.001 |
| June 2022 – March 2023d | 0.91 (0.85–0.97) | 0.006 | – | – | 0.92 (0.86–0.98) | 0.012 |
| Female sex | 1.20 (1.08–1.33) | <0.001 | 0.95 (0.61–1.46) | 0.808 | 1.22 (1.10–1.35) | <0.001 |
| ≥3 persons in household | 1.13 (1.02–1.26) | 0.017 | 2.69 (1.62–4.46) | <0.001 | 1.08 (0.97–1.20) | 0.148 |
| Overweight/obese | 1.03 (0.93–1.14) | 0.561 | 1.31 (0.84–2.03) | 0.227 | 1.02 (0.91–1.13) | 0.784 |
| Current smoker | 0.73 (0.65–0.83) | <0.001 | 0.78 (0.46–1.31) | 0.345 | 0.73 (0.65–0.83) | <0.001 |
| Currently employed | 1.22 (1.08–1.38) | 0.002 | 1.32 (0.77–2.27) | 0.309 | 1.21 (1.07–1.37) | 0.003 |
| High educatione | 1.14 (1.03–1.26) | 0.014 | 1.39 (0.89–2.15) | 0.144 | 1.12 (1.01–1.25) | 0.032 |
| Prior SARS-CoV-2 infection | 0.43 (0.35–0.51) | <0.001 | 0.19 (0.06–0.61) | 0.005 | 0.44 (0.36–0.53) | <0.001 |
| Other pre-existing conditions | ||||||
| Cardiovascular disease | 1.20 (1.01–1.42) | 0.036 | 0.82 (0.37–1.82) | 0.630 | 1.22 (1.03–1.46) | 0.024 |
| Diabetes mellitus | 0.79 (0.53–1.18) | 0.253 | 3.40 (1.29–8.92) | 0.013 | 0.67 (0.43–1.03) | 0.069 |
| Chronic lung disease | 1.26 (0.98–1.63) | 0.072 | 3.21 (1.60–6.47) | 0.001 | 1.14 (0.87–1.50) | 0.346 |
| Cancer | 0.93 (0.69–1.25) | 0.649 | 0.82 (0.20–3.37) | 0.778 | 0.95 (0.70–1.28) | 0.716 |
| Renal disease | 1.22 (0.78–1.91) | 0.392 | 0.97 (0.13–7.23) | 0.979 | 1.25 (0.79–1.98) | 0.345 |
| Liver disease | 1.26 (0.71–2.25) | 0.429 | 1.76 (0.24–12.90) | 0.579 | 1.25 (0.68–2.28) | 0.476 |
| Intake of immunosuppressants | 1.10 (0.68–1.77) | 0.706 | 1.04 (0.14–7.57) | 0.966 | 1.09 (0.67–1.79) | 0.732 |
Analyses included participants with complete data on all characteristics (for more details see Table S1).
The Cox regression model was adjusted for all characteristics mentioned in the table and an interaction term of age with time split at June 1, 2022.
The Cox regression model was adjusted for all characteristics mentioned in the table, an interaction term of age with time split at June 1, 2022, and interaction terms of all of these variables with time split at December 1, 2021.
This period starts at March 15, 2021 and ends at May 31, 2022.
This period starts at June 1, 2022 and ends at March 15, 2023.
High education was defined as vocational school, Advanced level, or university diploma. Abbreviations: CI, confidence interval; HR, hazard ratio; SARS-CoV-2, severe acute respiratory syndrome coronavirus type 2. After correcting for multiple testing, p-values<0.003 (0.05/16 covariates) are deemed statistically significant, which are marked in bold.