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. 2024 Sep 6;15(6):2828–2851. doi: 10.14336/AD.2024.0241

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Copyright: © 2024 Di Emidio et al.

this is an open access article distributed under the terms of the creative commons attribution license, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

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Figure 3. — Differentially expressed genes involved in NAD⁺ metabolism in young and aged MII oocytes and Ingenuity pathway analysis (IPA)-generated functional analysis. (A) Histograms of significant mean fold change values for all differentially expressed genes in physiological aged oocytes compared to young controls. Pools of 25 oocytes isolated from 3-6 mice were employed. The experiment was repeated three times. Statistical analysis by paired t-test: ^*p<0.05. (B) IPA-interfered target gene network for NAD⁺ metabolism of physiologically aged MII oocytes compared to controls. Tnks2 gene is the central node of IPA-interfered target gene network for NAD⁺ metabolism of physiologically aged oocytes in comparison to young oocytes. In red the up-regulated genes, while in green the down-regulated ones. Blue arrow lines indicate a predicted inhibition. (C) The bar-chart is generated based on a -log (p-value) threshold of 0.05 and indicates the main significant biological functions regulated by our gene dataset in aged oocytes.