Table 4. Anti-TB activity prediction of top drugs through online server mycoCSM.

Compound	Predicted Mtb. MIC (log μM)	Caseum FU (%)	MRTD log (mg/kg/day)
Diacerein	-4.732	6.593	0.288
Levonadifloxacin	-5.429	15.609	1.005
Gatifloxacin	-5.488	21.732	0.929
Rifampicin	-6.312	7.493	1.106
Isoniazid	-4.942	67.2	1.166

MRTD, Maximum Recommended Therapeutic Dose. Note: Caseum FU (%) represents the predicted ability of compounds to penetrate necrotic tuberculosis foci, with higher values indicating a greater likelihood of penetration into these foci.