Figure 4.

Thirty-day survival curves. The 30-d survival curves are displayed according to the subtypes on ICU admission and day 2 in the Molecular diAgnosis and Risk stratification of Sepsis (MARS) and Medical Information Mart for Intensive Care-IV (MIMIC-IV) cohort. Only patients with the δ and γ subtypes were included in this figure, since the α and γ subtypes were only present in a small proportion of the MARS (on baseline α = 6.2% and β = 2.9%). The logistic regression model between the survival curves of the patients with consistent subtype on ICU admission vs. those exhibiting a changed subtype by day 2 is shown. The model showed significant differences in the MARS between γ-γ and γ-δ (***), δ-δ (***) and δ-γ (*) between δ-γ and δ-δ (***) and γ-δ (*). The model showed significant differences in the MIMIC-IV cohort between δ-δ and γ-γ (***), γ-δ (***) and δ-γ (***). *p < 0.05, **p < 0.01, and ***p < 0.001. *p < 0.05, **p < 0.01, and ***p < 0.001.